What is graft-versus-host disease?

Graft-versus-host disease is a complication that can occur following an allogeneic hematopoietic stem cell transplantation.

Types

There are two distinct forms of graft-versus-host disease (GvHD), acute and chronic GvHD.

Causes and symptoms

Graft-versus-host disease can occur following allogeneic hematopoietic stem cell transplantation when the donor cells identify the recipient's tissue as foreign and attack it. Symptoms can range from mild to severe and, in some cases, life-threatening.

Diagnosis

Several different tests are used to diagnose graft-versus-host disease in patients who experience symptoms, including physical examinations, laboratory tests, biopsies, and imaging.

Treatment

The goal of treatment for graft-versus-host disease is to manage a patient's symptoms and prevent any further damage to their organs.

Prognosis and response to treatment

The prognosis, or outlook, for patients with graft-versus-host disease can vary depending on several factors, including which organs are affected and how they respond to treatment.

Steroid-refractory GvHD

Corticosteroids are often the first treatment used for acute or chronic graft-versus-host disease. Healthcare professionals may further describe graft-versus-host disease based on how well the condition responds to corticosteroid therapy.

Caregivers

Being a caregiver for someone with graft-versus-host disease involves supporting them with everyday activities, and it can be both physically and mentally challenging.