What is graft-versus-host disease?

Graft-versus-host disease (GvHD) is a complication that can occur following an allogeneic hematopoietic stem cell transplantation.

Types

There are two distinct forms of graft-versus-host disease (GvHD), acute and chronic.

Causes and symptoms

Graft-versus-host disease (GvHD) is a complication that can occur after allogeneic hematopoietic stem cell transplantation, when a type of white blood cells, called T cells, are made from stem cells from the donor and identify the recipient's tissue as foreign and attack it.

Diagnosis

Several different tests are used to diagnose graft-versus-host disease in patients who experience symptoms, including physical examinations, laboratory tests, biopsies, and imaging.

Treatment

The goal of treatment for graft-versus-host disease is to manage a patient's symptoms and prevent any further damage to their organs.

Prognosis and response to treatment

The prognosis, or outlook, for patients with graft-versus-host disease can vary depending on several factors, including which organs are affected and how they respond to treatment.

Steroid-refractory GvHD

Corticosteroids are often the first treatment used for acute or chronic graft-versus-host disease. Healthcare professionals may further describe graft-versus-host disease based on how well the condition responds to corticosteroid therapy.

Caregivers

Being a caregiver for someone with graft-versus-host disease involves supporting them with everyday activities, and it can be both physically and mentally challenging.